CAM1 — Sorghum bicolor

Summary

SORBI_3001G013400 (SbCAM1) on sorghum chromosome 1 encodes a kinetochore protein Nuf2 N-terminal domain-containing protein. The gene is associated with diverse molecular functions including vitamin Bt transporter, S-nitrosoglutathione reductase, carbohydrate transmembrane transporter, and SUMO transferase activities, as well as calcium ion and RNA binding. It is linked to kinetochore organization, meiotic chromosome segregation, ERAD pathway, and responses to cold, drought, and salinity. Associations also include leaf senescence, seed development, heat acclimation, and lignin anabolism. The encoded protein localizes to the Ndc80 complex, chromatin, tonoplast, chloroplast envelope, plastid, mitochondria, and cytosol. SbCAM1 is associated with traits such as iron sensitivity, shoot branching, stomatal closure, flowering time, photosynthetic rate, root development, disease tolerance, and abscisic acid sensitivity. Studies of related genes in other species link the family to cadaverine sensitivity, drought and salt stress tolerance, formaldehyde detoxification, and thermotolerance.