CAM1 — Sorghum bicolor

Summary

SbCAM1 (SORBI_3001G016200) on sorghum chromosome 1 encodes a protein containing a Kinetochore_Nuf2_N domain and is annotated with multiple molecular functions including vitamin Bt transporter activity, S-nitrosoglutathione reductase activity, carbohydrate transmembrane transporter activity, monoatomic ion channel activity, calcium ion binding, and chaperone protein binding. The gene is associated with kinetochore organization, meiotic chromosome segregation, mitotic spindle organization, ERAD pathway, cellular responses to cold, salinity, and drought, lignin anabolism, leaf senescence, seed development, and heat acclimation. It localizes to the Ndc80 complex, chromatin, tonoplast, chloroplast envelope, plastid, mitochondria, and cytosol. Associations include iron sensitivity, shoot branching, stomatal closure, photosynthetic rate, flowering time, disease tolerance, salt tolerance, root development, and abscisic acid sensitivity. Studies of related genes in other species link the family to cadaverine sensitivity, drought and salt stress tolerance, freezing tolerance, thermotolerance, formaldehyde detoxification, and iron toxicity tolerance.