ROS1 — Nicotiana attenuata

Summary

A4A49_45693 (ROS1) in coyote tobacco (Nicotiana attenuata) encodes a DNA glycosylase with cytosine C-5 DNA demethylase activity, belonging to the DME/ROS1 family and containing an endonuclease III Fe-S loop motif and HhH base-excision C domain. The gene is associated with chromosomal 5-methylcytosine DNA demethylation via the direct excision pathway, base excision repair, epigenetic regulation of gene expression, pigment accumulation, and anthocyanin anabolism. It is linked to drought tolerance and localizes to the nucleus. Studies of related genes in other species connect the ROS1 family to flavonoid, anthocyanin, and chlorophyll content, as well as plant height and salt tolerance.