ROS1 — Nicotiana attenuata

Summary

A4A49_34776 (ROS1) in coyote tobacco (Nicotiana attenuata) encodes a DNA glycosylase with cytosine C-5 DNA demethylase, AP deoxyendoribonuclease, and lyase activities, and binds 4Fe-4S clusters and DNA. It is associated with chromosomal 5-methylcytosine DNA demethylation via the direct excision pathway, base excision repair, epigenetic regulation of gene expression, pigment accumulation, and anthocyanin biosynthesis. The protein localises to the nucleus. ROS1 has also been connected to drought tolerance. Related genes in other species link the family to additional DNA glycosylase functions.