HSP70 — Nicotiana attenuata

Summary

A4A49_08601 (HSP70) on chromosome 2 of coyote tobacco (Nicotiana attenuata) encodes a heat shock protein 70 family member with ATP hydrolase activity, ATP binding, heat shock protein binding, and protein folding chaperone functions. This gene is associated with protein folding and refolding, the ERAD pathway, the unfolded protein response (erUPR), calcium signaling, signal transduction, defense response, response to heat, stress, and virus, viral translation, virus-induced PTGS, phytochelatin anabolism, leaf senescence, pollen tube growth, and cell division. It localizes to the ER chaperone complex, ER lumen, chloroplast membrane, membrane, cytoplasm, and nucleus. Associations with seed weight, seed size, lignin content, stomatal resistance, and chlorophyll content have been noted. Studies of related genes in other species link this gene family to ER stress responses and protein quality control.