NIC2 — Nicotiana attenuata

Summary

A4A49_08799 (NIC2) in coyote tobacco (Nicotiana attenuata) on chromosome 2 encodes a protein with isochorismatase-like hydrolase domains and exhibits nicotinamidase activity, along with hydrolase activity, mRNA binding, and zinc binding. It is associated with nicotine metabolism, NAD metabolism, polyamine metabolism, and alkaloid anabolism, as well as responses to nicotine, cold, and acid chemicals. The gene is linked to cold acclimation, innate immunity, signal transduction, and polar cell growth, and its product localizes to the cytoplasm, nucleus, and mitochondria. Associations include low temperature stress response, salt tolerance, drought tolerance, freezing tolerance, ABA sensitivity, seed germination, and leaf cell expansion. Related genes in other species link the family to biomass and increased NAD levels.