CAD — Nicotiana attenuata

Summary

A4A49_08174 (CAD) in coyote tobacco (Nicotiana attenuata) encodes a cinnamyl-alcohol dehydrogenase-like protein with oxidoreductase activity acting on CH-OH groups using NAD or NADP as acceptor, and exhibits geraniol dehydrogenase, vomilenine reductase, mannitol dehydrogenase, 8-hydroxygeraniol dehydrogenase, and cinnamyl-alcohol dehydrogenase activities, along with zinc binding. The gene is associated with phenylpropanoid metabolism, lignin anabolism, flavonoid anabolism, alkaloid metabolism, pigmentation, glycan biosynthesis, primary metabolism, photorespiration, detoxification, and carbohydrate metabolism. It is linked to oviposition and localised to the cytoplasm. Associations with lignin content and starch mobilisation have also been noted. Studies of related genes in other species connect the family to cinnamyl-alcohol dehydrogenase and vomilenine reductase activities.