M2 — Lactuca sativa

Summary

LsM2, also known as CYP22 or LsCYP18-2, encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) on lettuce chromosome 9. The encoded protein possesses cyclosporin A binding, peroxidase activity, and is annotated with numerous molecular functions including histone, chromatin, and salicylic acid binding, as well as U2 and U5 snRNA binding. LsM2 is associated with sesquiterpenoid metabolism, lactone biosynthesis, protein proline isomerization, and the regulation of ARF protein signal transduction. It has been linked to traits including variegated leaf, heterosis, starch grain synthesis, respiration rate, photosynthetic rate, sucrose content, herbicide sensitivity, and responses to temperature stress, light intensity, and zinc. The gene is also associated with heat stress tolerance, pathogen defense, disease resistance, and root hydrotropism. Related genes in other species are linked to water stress tolerance, cold stress response, hydrotropism, and phototropism.