M2 — Lactuca sativa

Summary

LsM2, on lettuce chromosome 9, encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) with annotated cis-trans proline isomerase activity, cyclosporin A binding, salicylic acid binding, and peroxidase activity. It is associated with sesquiterpenoid metabolism, lactone biosynthesis, protein proline isomerization, chaperone-mediated protein complex assembly, and alternative mRNA splicing via the spliceosome. The gene has been connected to numerous traits including variegated leaf, heterosis, starch grain synthesis, respiration rate, temperature stress response, zinc sensitivity, phototropism, sucrose content, herbicide sensitivity, root hair length, chloroplast development, jasmonic acid content, photosynthetic rate, and stomatal closure. It is also linked to heat stress tolerance, pre-mRNA splicing, seedling growth, pathogen defense, disease resistance, and auxin transport. Studies of related genes in other species link the cyclophilin family to water stress tolerance, cold stress response, hydrotropism, phototropism, embryo patterning, and drought response.