PMIT1 — Lactuca sativa

Summary

LsPMIT1, also known as PMIT1, is a lettuce gene on chromosome 2 that encodes a member of the NRAMP family of metal ion transporters. The product has metal ion, manganese ion, iron channel, and cadmium ion transmembrane transporter activities. It is associated with manganese ion homeostasis and transport, iron and cadmium ion membrane transport, lead ion transport, regulation of vacuolar transport, and positive regulation of the ROS metabolic process. The protein localizes to the tonoplast, vacuolar membrane, trans-Golgi network membrane, endosome membrane, plastid, and plasmodesma. The gene is linked to photosynthetic rate, root length, and plant height, as well as phenotypes including growth under manganese deficiency, copper homeostasis, cadmium transport, iron remobilization, manganese uptake and translocation, seed germination, and photosystem II activity. Studies of related genes in other species connect the family to traits such as iron and manganese sensitivity, bacterial blight resistance, cadmium concentration, and oxidative stress tolerance.