MS1 — Lactuca sativa

Summary

LsMS1 (MS1) on lettuce chromosome 2 encodes a cobalamin-independent methionine synthase, a protein with domains characteristic of this enzyme family. The gene is associated with de novo L-methionine biosynthesis, regulation of starch biosynthesis, and protein poly-ADP-ribosylation. It has been linked to responses to ozone, oxidative stress, hypoxia, bacteria, insects, and zinc, as well as induced systemic resistance, defense response by callose deposition, and innate immune signaling. Associations with whole plant size, seed growth and development, root morphology, disease tolerance, salt tolerance, and plant stress responses have been noted. The gene product localizes to multiple cellular compartments including the chloroplast envelope and stroma, apoplast, vacuole, Golgi, plasmodesmata, mitochondria, cytosol, and plasma membrane. Related genes in other species are linked to male sterility, pollen development, chromatin silencing, and defense activation.