ERD2 — Hordeum vulgare subsp. vulgare

Summary

HORVU.MOREX.R3.6HG0620330 (HvERD2) on barley chromosome 6H encodes a member of the Hsp70 family of ATP-dependent protein folding chaperones, containing the characteristic heat shock protein 70 domains. The gene is associated with a wide range of molecular functions including calcium-dependent phospholipid binding, DXP-synthase activity, D-glucose binding, preprotein binding, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase, protease binding, Hsp90 binding, histone H3K18 acetyltransferase activity, poly-A binding, ATP-dependent peptidase activity, heat shock protein binding, and amino acid permease activity. It is linked to biological processes such as cell glucose homeostasis, upregulation of cellular defense response, response to humidity, cytosol-to-ER transport, protein localization to chloroplast, RuBisCO assembly, cellular response to salicylate stimulus, and regulation of cell cycle G1/S phase transition. The gene is associated with agronomically relevant traits including grain filling period, biomass yield, photosynthetic ability, carotenoid content, nitrate uptake, and responses to temperature, salt, chilling, and various hormones. Studies of related genes in other species link the Hsp70 family to heat stress tolerance, leaf senescence, hybrid necrosis, and disease resistance.