HSP70 — Hordeum vulgare subsp. vulgare

Summary

HORVU.MOREX.R3.6HG0621280 (HSP70) on barley chromosome 6H encodes an ATP-dependent protein folding chaperone belonging to the Hsp70 family, characterised by a heat shock protein 70 signature, peptide-binding domain and ATPase domain. The gene product binds ATP and has ATP hydrolase activity, and is associated with protein refolding, the ERAD pathway, the unfolded protein response, and protein folding in the endoplasmic reticulum. It is linked to stress responses including heat, virus infection, immune response and innate immunity, as well as lipid metabolism and response to thirst. The protein localises to the ER lumen, ER chaperone complex, cytoplasm, nucleus, chloroplast membrane, tonoplast and membrane. Studies of related genes in other species link the family to spikelet number.