PAP5 — Hordeum vulgare subsp. vulgare

Summary

HORVU.MOREX.R3.6HG0623260 (HvPAP5, also known as HvSAG12) on barley chromosome 6H encodes a papain-like cysteine peptidase, possessing thiol endopeptidase and cysteine-type peptidase activity. The gene is associated with leaf senescence, programmed cell death, and proteolysis, and is linked to responses to abscisic acid, ethylene, and gibberellin. It is associated with the mevalonate (MVA) and methylerythritol phosphate (MEP) pathways, as well as developmental processes, regeneration, and cell death. The encoded protein localises to the senescence-associated vacuole, lysosome, protein storage vacuole, and ER lumen. Studies of related cysteine proteinases in other species link the family to similar proteolytic functions during senescence and development.