PAP5 — Hordeum vulgare subsp. vulgare

Summary

HORVU.MOREX.R3.6HG0622170, designated HvPAP5 (also known as HvSAG12), encodes a papain-like cysteine peptidase of the C1A family, possessing thiol endopeptidase and cysteine-type peptidase activity. In barley, this gene is associated with leaf senescence, programmed cell death, and proteolysis, and is linked to responses to abscisic acid, ethylene, and gibberellin. It is also associated with the mevalonate (MVA) and methylerythritol phosphate (MEP) pathways, as well as regeneration and developmental processes. The encoded protein localises to the senescence-associated vacuole, protein storage vacuole, lysosome, and ER lumen. Studies of related genes in other species link the family to similar roles in senescence and proteolysis.