FLBA — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoFLBA (FLBA) of Fusarium oxysporum f. sp. lycopersici 4287 encodes a regulator of G-protein signalling (RGS) protein containing DEP and RGS domains, with GTPase-activating protein (GAP) activity. The gene is associated with the negative regulation of GPCR signalling, the pheromone response MAPK cascade, and the regulation of conidium formation and asexual sporulation. It is linked to both the breakdown and positive regulation of sterigmatocystin biosynthesis, as well as regulation of secondary metabolite biosynthesis, intracellular signal transduction, and transcription by RNA polymerase II. The product localises to the cytoplasm, cytosol, nucleus, and internal side of the plasma membrane. Phenotypic associations include altered mating response, pheromone sensitivity, shmoo formation, osmotic stress resistance, endocytosis, vesicle distribution, nuclear fusion during mating, and sterile phenotype. Studies of related genes in other species link the family to pheromone desensitisation and recovery from cell cycle arrest.