CHS1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoCHS1 (CHS1) on chromosome 7 of Fusarium oxysporum f. sp. lycopersici encodes a chitin synthase, an enzyme with chitin synthase activity that belongs to the chitin synthase family. The gene is associated with cell wall biogenesis and organization, chitin anabolism, conidia formation, hyphal growth, and homologous recombination. Its product localizes to the plasma membrane, hyphal tip, porous cell septum, cross wall, and cell periphery. Phenotypic associations include abnormal chitin deposition, septum formation, spore wall formation, budding, cell fusion, shmo formation, and bipolar budding pattern, as well as decreased flocculation and adhesion, increased pheromone sensitivity, altered cell cycle progression (including G2 phase duration, late anaphase arrest, and premature metaphase/telophase), and increased survival rate in stationary phase. Studies of related genes in other species link them to reduced virulence and lethal phenotypes.