LAC1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoLAC1 (FOXG_17179) in Fusarium oxysporum f. sp. lycopersici 4287 encodes a ceramide synthase, a member of the Lag1/Lac1-like family containing TRAM1 and TLC domains. The gene is associated with ceramide and sphingolipid anabolism, detoxification, the meiotic cell cycle, and endocytosis, and its product localizes to the endoplasmic reticulum membrane. FoLAC1 has been linked to expression detected during tomato infection at 2, 4, and 6 days post-inoculation, as well as under in vitro conditions. Studies of related genes in other Fusarium species connect the family to sphingolipid metabolism. The gene is also associated with fumonisin and alternariol toxin biosynthesis proteins.