ADH1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoADH1 (FOXG_16228) on chromosome 6 of Fusarium oxysporum f. sp. lycopersici 4287 encodes an aldo-keto reductase with NAD-binding and zinc-binding activity, belonging to the alcohol dehydrogenase (ADH) family. The gene is associated with the breakdown of acetaldehyde, ethanol, and threonine, as well as with cellular response to farnesol. Its product localises to the cytoplasm, mitochondrial lumen, extracellular space, and fungal biofilm matrix. FoADH1 is linked to the related genes patD, alcC, ADH2, and ADH6. Studies of related genes in other species, including Fusarium and Verticillium species, connect it to alcohol dehydrogenase (EC 1.1.1.1) activity, though these associations are not yet established for FoADH1 itself.