FLBA — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoFLBA (FLBA, FOXG_16355) in Fusarium oxysporum f. sp. lycopersici 4287 encodes a protein with GTPase-activating (GAP) activity, containing regulator of G-protein signaling (RGS) and DEP domains, and is located at the internal side of the plasma membrane, cytoplasm, cytosol, and nucleus. The gene is associated with regulation of conidium formation, asexual sporulation, the pheromone response MAPK cascade, sterigmatocystin breakdown and biosynthesis, and negative regulation of GPCR signaling. Phenotypic associations include altered mating response, pheromone sensitivity, shmoo formation, osmotic stress resistance, endocytosis, vacuolar transport, and increased chemical compound excretion. It is also linked to regulation of secondary metabolite biosynthesis, lipid metabolism, protein breakdown, and transcription by RNA polymerase II. Studies of related genes in other species connect the family to germination rate and oxidative stress response.