bik1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FOXG_04758 (bik1) on chromosome 7 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a thioesterase with an AB_hydrolase domain and multiple annotated enzyme activities, including adenosylmethionine decarboxylase, fatty acid synthase, ketoacyl-ACP synthase, and redox activity. The gene is associated with effector-mediated suppression of host pattern-triggered immunity, response to host, and asexual spore wall assembly. It is linked to DHN-melanin biosynthesis, polyketide and antibiotic anabolism, secondary metabolism, conidia and spore formation, and pigment metabolic processes involved in developmental pigmentation. The encoded protein is also associated with endosome localisation. Studies of related genes in other species link the bik1 family to polyketide synthase function and, in some cases, reduced virulence, though pathogenicity is unaffected in others.