CAD2 — Arabidopsis thaliana

Summary

AT4G23100 (CAD2, also known as GSH1, RML1, PAD2, and AtECS1) encodes a gamma-glutamylcysteine synthetase (glutamate-cysteine ligase, EC 6.3.2.2). The enzyme localizes to the chloroplast stroma, plastid, and cytosol. In Arabidopsis, the gene is associated with glutathione content and accumulation, cadmium sensitivity, zinc transport from roots to shoots, pathogen resistance, nematode resistance, and flowering time. It is linked to processes including glutathione anabolism and catabolism, phytochelatin anabolism, indole phytoalexin anabolism, dormancy, seed dehydration, membrane depolarization, phloem unloading, and the ascorbate-glutathione cycle. Associations also extend to traits such as drought tolerance, submergence tolerance, photosynthetic rate, chlorophyll content, leaf senescence, root development, and meristem identity.