AT4G18710 — Arabidopsis thaliana

Summary

AT4G18710 (BIN2, also known as SK21, DWF12, UCU1) on chromosome 4 of Arabidopsis thaliana encodes a non-specific serine/threonine protein kinase belonging to the GSK-3 family. The encoded protein has been annotated with diverse molecular functions including gamma-tubulin complex binding, MAPKK activity, transcription regulator activity, and histone H2AS1 kinase activity. BIN2 is associated with numerous biological processes such as regulation of microtubule nucleation and stabilization, upregulation of cytokinesis, thermomorphogenesis, macroautophagy, and positive regulation of ethylene biosynthesis. It is linked to traits including grain size, seed volume and shape, tiller angle, stem dry weight, harvest index, leaf area, root width, sodium content, and fruit quality. The gene is also associated with vascular development, cambium homeostasis, nematode resistance, and root epidermal cell patterning. Studies of related genes in other species link the family to disease resistance, trichome development, and root-hair pattern formation.