EDM1 — Arabidopsis thaliana

Summary

AT4G11260 (EDM1, also known as SGT1B) encodes a protein with Sgt1-like and HSP20-like chaperone domains that exhibits calcium-dependent phospholipid binding, Hsp90 binding, ubiquitin ligase binding, SUMO transferase activity, and chaperone protein binding. In Arabidopsis thaliana, this gene is associated with disease susceptibility and downy mildew resistance, as well as the upregulation of cellular defense responses, respiratory burst involved in defense, regulation of protein stability, and negative regulation of hypersensitive response. It localizes to the nuclear matrix, perinuclear region, SCF complex, and stress granules. The gene has been linked to numerous traits including root width and weight, leaf shape, photosynthetic rate, auxin and brassinosteroid sensitivity, germination rate, cadmium concentration, and responses to temperature stress, bacterial disease, and insect damage. Studies of related genes in other species connect the family to resistance against Fusarium head blight and Pseudomonas syringae.