ATM — Arabidopsis thaliana

Summary

AT3G48190, also known as ATM, encodes a protein with phosphatidylinositol-3-phosphate 5-kinase activity, metal binding, protein serine/threonine kinase activity, and protein binding, containing ATM_plant, PIK_FAT, PIK-rel_kinase_FAT, and ARM-type_fold domains. In Arabidopsis thaliana, this gene is associated with DNA integrity checkpoint, replication fork arrest, bypass DNA synthesis, canonical nonhomologous end joining, DNA damage response, telomere maintenance, cell cycle checkpoint, induction of programmed cell death, G2 phase, DNA replication checkpoint, homologous chromosome segregation, meiosis I, meiotic DNA double-strand break formation, multicellular organismal reproductive process, prophase, M phase, signaling, and regulation of telomere maintenance. It localizes to the PRC2 complex, HDAC complex, Cul4-RING E3 ubiquitin ligase complex, nucleolus, plasmodesma, mitochondria, cytosol, cytoplasm, and nucleus. ATM is linked to traits including plastochron, radiation response, phosphorus response, phyllotaxy, adventitious rootless, meristem identity, cell cycle, root development, leaf senescence, flowering time, disease tolerance, and root morphology. Phenotypic associations include telomere length homeostasis, cell cycle progression, telomere protection, telomere length, telomere function, meiotic recombination, gamma-radiation tolerance, severely reduced fertility,