ATG5 — Arabidopsis thaliana

Summary

AT3G51830 (ATG5, SAC8) on chromosome 3 of thale-cress encodes a SAC domain-containing protein with phosphatidylinositol-4-phosphate phosphatase activity. The gene is associated with autophagy, including macroautophagy, microautophagy, lipophagy, and mitophagy, as well as pexophagy. It is linked to ultraviolet-B sensitivity, osmotic stress tolerance, oxidative stress tolerance, pathogen tolerance, heat stress tolerance, high light and heat stress tolerance, and heat stress recovery. Associations with seed yield, biomass, harvest index, seed protein content, nitrogen recycling, and nitrogen starvation tolerance have been observed. The encoded product localises to the plasma membrane, ER membrane, mitochondria, cytosol, and plasmodesmata, and is connected to root hair and pollen tube tip growth, chloroplast development, and phosphatidylinositol phosphate homeostasis.