RIN4 — Arabidopsis thaliana

Summary

AT3G25070 (RIN4) encodes a RIN4/NOI4 family protein with a Type III avirulence factor Avr cleavage site domain, annotated with clathrin light chain binding, proton-transporting ATPase activity, structural molecule activity, and enzyme modulator functions. In Arabidopsis, RIN4 is associated with innate immune response, phytoplasma resistance, and plant immune response, as well as regulation of signaling, protein phosphorylation, detection of bacteria, salicylic acid anabolism, and negative regulation of the hypersensitive response. It localizes to the plasma membrane, endomembrane system, stress granules, and chloroplast envelope. The gene is linked to traits including bacterial blight disease resistance, leaf necrosis, root hair density, inflorescence size, cadmium concentration, and alkali soil sensitivity. Studies of related genes in other species connect the family to susceptibility to bacterial pathogens with avrRpm1, avrB, or avrRpt2, and defective flagellin-induced bacterial resistance.