CENH3 — Arabidopsis thaliana

Summary

AT1G01370, also known as CENH3 or HTR12, encodes a centromeric histone H3 variant that is a structural constituent of chromatin and binds DNA, histones, and methylated DNA. This gene is associated with centromere identity, organization, and targeting, as well as kinetochore assembly and meiotic chromosome segregation. CENH3 has been linked to haploid production, uniparental genome elimination, and clonal reproduction, along with plant growth, fertility, and meiotic genome stability. It is also connected to flowering time, seed dormancy, plant height, root morphology, and floral organ development. The protein localizes to the centromere complex, kinetochore, chromocenter, and nucleus. Related genes in other species are linked to centromere DNA methylation and epigenetic silencing.