FRD1 — Arabidopsis thaliana

Summary

AT1G01580 (FRD1, FRO2) in Arabidopsis thaliana encodes a ferric-chelate reductase (NADH:Fe3+ oxidoreductase, EC 1.16.1.7) with a ferric reductase transmembrane domain and FAD-binding domains, placing it in the RBOH/FRE protein family. The gene is associated with iron uptake, iron homeostasis, and ferric chelate reductase activity, as well as responses to iron deficiency, including root growth under iron limitation and root system iron content. It has been linked to cadmium concentration, leaf chlorosis, photosynthetic rate, disease tolerance, cold and chilling tolerance, and leaf senescence. Additional associations include coumarin and sideretin biosynthesis, auxin transport, phloem loading, and localization to the plasma membrane and nucleus. Studies of related genes in other species link the family to chlorophyll content, salt tolerance, and seed germination.