MYCGR3G76503 — Zymoseptoria tritici

Summary

MYCGR3G76503 (GPA2) on Zymoseptoria tritici chromosome 10 encodes a guanine nucleotide-binding protein alpha subunit, belonging to the fungal G-protein alpha family and containing a GproteinA_insert domain. The product exhibits GTPase activity, GTP binding, guanyl nucleotide binding, G protein-coupled receptor binding, and G-protein beta/gamma-subunit complex binding. GPA2 is associated with the heterotrimeric G-protein complex and cytoplasm. It is linked to GPCR signaling pathways, including adenylate cyclase activation and cAMP signaling, as well as glucose detection and import. The gene is associated with regulation of conidium formation, sporocarp development involved in sexual reproduction, pheromone-dependent signal transduction in conjugation, and regulation of secondary metabolite biosynthesis, including sterigmatocystin and penicillin anabolism. Studies of related genes in other species link the family to reduced virulence, germination rate, protein content, and oxidative stress.