MYCGR3G84968 — Zymoseptoria tritici

Summary

MYCGR3G84968 (ILV2) on chromosome 3 of Zymoseptoria tritici encodes a protein with acetolactate synthase activity, also annotated with pyruvate decarboxylase and 2-hydroxyacyl-CoA lyase activities, and binds TPP, magnesium, and FAD. The gene is associated with branched-chain amino acid biosynthesis, including valine, isoleucine, and L-isoleucine anabolism, as well as isobutanol anabolism, the Ehrlich pathway for aromatic amino acid catabolism, fatty acid alpha-oxidation, pyruvate metabolism, and fermentation. It is linked to mitochondrial and peroxisomal localisation, the acetolactate synthase complex, and cell wall components of both yeast and hyphal forms. Associations also include regulation of amino acid transport, mitochondrial protein quality control, morphogenesis, and homologous recombination. Studies of related genes in other species link the family to loss of pathogenicity and sensitivity to oxidative stress and acid.