MYCGR3G67344 — Zymoseptoria tritici

Summary

MYCGR3G67344, designated SSK2 on Zymoseptoria tritici chromosome 1, encodes a protein with protein serine/threonine kinase activity, MEKK activity, and MAPKKKK function. The gene is associated with multiple MAPK cascades, including stress-activated, cell integrity, pheromone response, JNK, and p38 pathways, as well as the HOG response and osmotic response. SSK2 is associated with fungal-type cell wall organization, melanin anabolism, hyphal growth, morphogenesis, contractile ring assembly, and induction of conjugation with cellular fusion. It is associated with response to oxidative stress, calcium signaling, cell cycle control, and upregulation of developmental processes. The product localizes to the plasma membrane, cytoplasm, cytosol, division septum, cell tip, and cell division site, and is part of the Mcs4 RR-MAPKKK complex. Studies of related genes in other species link the family to loss of pathogenicity and sensitivity to calcium and oxidative stress.