MYCGR3G70113 — Zymoseptoria tritici

Summary

ERG6 (MYCGR3G70113) on chromosome 3 of Zymoseptoria tritici encodes a sterol 24C-methyltransferase, placing it in the SMT/Erg6 family of SAM-dependent methyltransferases. The enzyme is associated with ergosterol and zymosterol metabolism, methylation, and sterol anabolism. The gene product localises to the endoplasmic reticulum, mitochondria, plasma membrane, and adiposomes. ERG6 is linked to membrane hyperpolarisation, vacuolar localisation and fusion, lipophagy, lipolysis, glucose import, secretion, signal transduction, mitotic recombination, the pentose-phosphate shunt, fermentation, demethylation, and hypersensitivity. Studies of related genes in other species link the family to reduced virulence, cell membrane stability, oxidative stress tolerance, and oleic acid content.