HSP70 — Sorghum bicolor

Summary

SORBI_3001G419500 (HSP70) on sorghum chromosome 1 encodes a heat shock protein 70 family member with ATP-dependent protein folding chaperone activity, ATP hydrolase activity, and heat shock protein binding. It is associated with protein folding in the endoplasmic reticulum, protein refolding, the ERAD pathway, the unfolded protein response, detoxification, protein breakdown, programmed cell death, response to stress, response to heat, response to virus, and cell death. The gene has been associated with heat tolerance. Its product localises to the ER chaperone complex, ER lumen, chloroplast membrane, tonoplast, membrane, cytoplasm, nucleus, axonemal central pair projection, and mediator complex. Studies of related genes in other species link the family to similar chaperone functions in stress responses and protein quality control.