ADH — Sorghum bicolor

Summary

SORBI_3001G097600 (SbADH) on sorghum chromosome 1 encodes a protein with S-nitrosoglutathione reductase (NADH) activity and S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity (EC 1.1.1.1), along with aldo-keto reductase and redox activities, calcium ion binding, and protein homodimerization activity. The gene is associated with responses to hypoxia, flooding, hydrogen peroxide, heat acclimation, and osmotic and salinity stress, as well as seed development, programmed cell death, and cellular respiration. It has been linked to traits including stem thickness, plant height, photosynthetic rate, leaf senescence, drought tolerance, herbicide sensitivity, and disease tolerance. Localization evidence places the product in the plastid, mitochondria, cytosol, nucleus, and plasmalemma. Studies of related genes in other species link the family to hypoxic stress response, freezing tolerance, and formaldehyde detoxification.