IRT1 — Sorghum bicolor

Summary

SORBI_3001G142900 (SbIRT1) on sorghum chromosome 1 encodes a ZIP family Fe(2+) transport protein 2 with metal ion transmembrane transporter activity for copper, zinc, manganese, iron, and cadmium, along with phosphoinositide, ubiquitin, mRNA, and protein binding. The gene is associated with cellular and multicellular iron homeostasis, response to iron, nickel and cadmium transport, zinc membrane transport, stress response to zinc, thiamin metabolism, cell wall modification, detoxification, secretion, MVB formation, endosome membrane budding, and downregulation of abscisic acid signaling. It localizes to the plasmalemma, endosome, late endosome membrane, TGN, ESCRT I complex, nucleus, and extracellular space. Associations include grain filling period, plant growth and development, salt tolerance, iron and zinc homeostasis, biomass production, cadmium detoxification, chlorophyll content, photosynthetic efficiency, root and leaf development, disease resistance, and chloroplast development. Related genes in other species are linked to iron acquisition, cadmium uptake, nickel accumulation, zinc homeostasis, and vacuolar biogenesis.