IRT1 — Sorghum bicolor

Summary

SORBI_3001G156800 (SbIRT1) on sorghum chromosome 1 encodes a ZIP family metal transporter with copper, zinc, manganese, iron, and cadmium ion transmembrane transporter activities, as well as phosphoinositide, ubiquitin, and mRNA binding. The gene is associated with cellular and multicellular iron homeostasis, response to iron, cadmium transport, nickel cation transport, stress response to zinc, regulation of cellular response to basic pH, downregulation of abscisic acid signaling, phenylpropanoid anabolism, cellular response to hypoxia, cell wall modification, and secretion. It localizes to the plasma membrane, endosome, late endosome membrane, TGN, ESCRT I complex, nucleus, and extracellular space. SbIRT1 is linked to grain filling period, plant growth and development, salt tolerance, iron and zinc uptake, cadmium detoxification and accumulation, iron deficiency tolerance, chlorophyll content, photosynthetic efficiency, disease resistance, chloroplast and leaf development, root and lateral root development, and biomass production. Related genes in other species are linked to cadmium uptake, iron acquisition, nickel accumulation, and plant growth.