FOX — Phaseolus vulgaris

Summary

PHAVU_002G221900, designated PvFOX on chromosome 2 of French bean (Phaseolus vulgaris), encodes a berberine bridge enzyme (BBE) family protein with FAD-binding and redox activity, annotated with cannabidiolate synthase, delta9-tetrahydrocannabinolate synthase, and tetrahydroberberine oxidase activities. The gene is associated with nicotine, cannabinoid, terpenoid, and alkaloid anabolism, as well as protein secretion, cellular response to hypoxia, and defence response to bacteria. Its product localises to vesicles, vacuole, apoplast, plant-type cell wall, endoplasmic reticulum, extracellular space, and cytoplasm. PvFOX is linked to ethylene sensitivity. Related genes in other species connect the family to seed maturation and dormancy, and to climate-related phenotypes such as temperature minima and maxima.