FOX — Phaseolus vulgaris

Summary

PHAVU_002G222000, designated PvFOX, encodes a berberine bridge enzyme (BBE) family protein with FAD binding and redox activity, annotated with cannabidiolate synthase, delta9-tetrahydrocannabinolate synthase, and tetrahydroberberine oxidase activities. This French bean gene on chromosome 2 is associated with cannabinoid and terpenoid anabolism, alkaloid metabolism, protein secretion, cellular response to hypoxia, and defence response to bacteria. PvFOX localises to the vesicle, vacuole, apoplast, plant-type cell wall, endoplasmic reticulum, and cytoplasm. It is associated with ethylene sensitivity. Studies of related genes in other species connect the gene family to seed maturation and dormancy traits, though these associations are not established for PvFOX itself.