SHD — Nicotiana attenuata

Summary

A4A49_64576 (NaSHD) on coyote tobacco (Nicotiana attenuata) chromosome scaffold07123 encodes a heat shock protein 90 (Hsp90) family member, containing Hsp90_C and Hsp90_fam domains, with ATP-dependent protein folding chaperone activity. The gene is associated with diverse molecular functions including 2',3'-cyclic-nucleotide 2'-phosphodiesterase, DNA polymerase, and transcription regulator activities, as well as Hsp90 binding. It has been linked to biological processes such as viral translation, cellular response to unfolded protein, respiratory burst involved in defense response, and double-strand break repair. NaSHD is associated with numerous traits including floral organ morphology, seed set percent, submergence tolerance, bacterial and viral disease response, temperature stress response, aphid response, and reproductive growth time. Localization evidence places the product at the chloroplast outer membrane, ER lumen, Tic complex, and cell periphery. Studies of related Hsp90 genes in other species connect the family to thermotolerance, broad-spectrum disease resistance, salinity tolerance, and chloroplast envelope maintenance.