CXE17 — Nicotiana attenuata

Summary

A4A49_42474 (CXE17) in coyote tobacco (Nicotiana attenuata) encodes a protein with carboxylesterase, 2-hydroxyisoflavanone dehydratase, isomerase, lyase, and hydrolase activities, belonging to the alpha/beta hydrolase and carboxylest/Gibb_receptor domain families. The gene is associated with defense response, systemic acquired resistance, immune response, hypersensitivity, programmed cell death, cell death, the MAPK cascade, signal transduction, and virus-induced PTGS. It is linked to salicylic acid anabolism, isoflavonoid anabolism, isoflavonoid metabolism, flavonoid anabolism, alkaloid metabolism, nucleoside anabolism, asexual sporulation, sporulation, and the metabolic burst. Localization evidence connects the product to the cytosol, nucleus, and amyloplast. The gene is associated with leaf necrosis and bacterial disease response. Studies of related genes in other species link the CXE17 family to disease resistance, and sequence similarity suggests connections to 2-hydroxyisoflavanone dehydratase activity and disease tolerance.