M2 — Nicotiana attenuata

Summary

A4A49_36232, designated NaM2 in coyote tobacco (Nicotiana attenuata) on scaffold00791, encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) with cyclosporin A binding and cis-trans proline isomerase activity. The gene is associated with nicotine metabolism, the methylerythritol phosphate (MEP) pathway, isoprenoid anabolism, secondary metabolism, demethylation, detoxification, excretion, protein folding, regulation of protein refolding, cell growth, seed germination, leaf development, and signal transduction. It is linked to responses to abscisic acid, salt, and mannitol, as well as activation of the salinity response. Localisation evidence links the product to the chloroplast stroma, cytosol, cytoplasm, nucleus, and plasmalemma. Associations with leaf length, root length, protein content, and salt tolerance (SALTTL) have also been recorded. Related genes in other species link the family to general protein folding and stress responses.