M2 — Nicotiana attenuata

Summary

A4A49_07191 (NaM2) in coyote tobacco (Nicotiana attenuata) encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) with cyclosporin A binding and cis-trans proline isomerase activity. This gene is associated with nicotine metabolism, the MEP pathway, isoprenoid anabolism, secondary metabolism, demethylation, detoxification, excretion, protein folding, regulation of protein refolding, cell growth, seed germination, leaf development, and responses to abscisic acid, salt, and mannitol. It is linked to activation of the salinity response and has been connected to leaf length, root length, and protein content. The product localizes to the chloroplast stroma, cytosol, cytoplasm, nucleus, plasmalemma, and catalytic step 2 spliceosome. Studies of related genes in other species link the family to general protein folding and stress responses.