SHD — Nicotiana attenuata

Summary

A4A49_03825 (SHD, NaSHD) in Nicotiana attenuata on chromosome 7 encodes a heat shock protein 90 (HSP90) family member, containing Hsp90 and HATPase domains, with ATP-dependent protein folding chaperone activity and additional annotated molecular functions including DNA polymerase and transcription regulator activities. The gene is associated with diverse biological processes such as cellular response to unfolded protein, viral translation, respiratory burst involved in defense response, double-strand break repair, and oviposition. It localizes to the chloroplast outer membrane, ER lumen, and Tic complex. Associations include floral organ morphology, seed set percent, submergence tolerance, bacterial and viral disease response, temperature stress response, aphid response, and gibberellin biosynthesis. Studies of related genes in other species link the HSP90 family to thermotolerance, broad-spectrum disease resistance, salinity tolerance, and chloroplast function.