RDR1 — Nicotiana attenuata

Summary

A4A49_04129 (RDR1) in coyote tobacco (Nicotiana attenuata) encodes an RNA-dependent RNA polymerase (EC 2.7.7.48) with RdRP activity and RNA binding, belonging to the RDRP family with RRM_RDR1/2-like and PH_RDR1/2-like domains. The gene is associated with posttranscriptional gene silencing, siRNA processing, and antiviral responses, and is linked to insect herbivore resistance, cuticular wax biosynthesis, and resistance to pathogens including Sclerotinia sclerotiorum and Fusarium brachygibbosum. It has been connected to drought resistance and maintenance of shoot apical meristem identity, with localisation to the nucleus and the RDRC complex. Studies of related genes in other species link the RDR1 family to viral resistance, leaf chlorosis, and plant height.