SHD — Nicotiana attenuata

Summary

A4A49_02690 (SHD, HSC80) in Nicotiana attenuata on chromosome 11 encodes an Hsp90 family chaperone with ATP-dependent protein folding activity and a range of annotated molecular functions including DNA polymerase, transcription regulator, and pectate lyase activities. The gene is associated with diverse biological processes such as viral translation, cellular response to unfolded protein, respiratory burst in defense response, and negative regulation of cellulose anabolism. It has been linked to numerous traits including floral organ morphology, seed set percent, bacterial and viral disease response, submergence tolerance, temperature stress response, aphid response, and photoperiod-sensitive flowering time. Localization evidence connects the product to the chloroplast outer membrane, ER lumen, and plasma membrane periphery. Studies of related genes in other species link the family to thermotolerance, broad-spectrum disease resistance, and salinity tolerance.