GCN2 — Nicotiana attenuata

Summary

A4A49_01454, the GCN2 gene on chromosome 7 of coyote tobacco (Nicotiana attenuata), encodes a protein with eukaryotic translation initiation factor 2alpha kinase activity, non-membrane spanning protein tyrosine kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity, protein tyrosine kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, and ATP binding. This gene is associated with translation initiation and protein synthesis, as well as responses to UV-C, wounding, cold, cadmium, and bacterial and fungal pathogens. It is linked to abscisic acid (ABA) signaling and anabolism, stomatal closure, seed germination, and activation of the salinity response. Associations with drought tolerance, leaf relative water content, chlorophyll content, and stomatal opening have also been noted. The encoded protein localises to the cytosol, cytoplasm, and nucleus. Studies of related genes in other species connect the broader family to cell cycle regulation and stress signaling.