CYP — Medicago truncatula

Summary

MTR_1G094065, designated MtCYP21-4, encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) on barrel medic chromosome 1. The product possesses cis-trans proline isomerase activity and binds cyclosporin A. It is associated with protein folding and the regulation of protein refolding, as well as electron transfer and triterpenoid anabolism. The gene has been connected to responses to abscisic acid, salt, and mannitol, and to activation of the salinity response. It is linked to shoot development and leaf necrosis. The protein localises to multiple cellular compartments including the cytosol, nucleus, chloroplast stroma, Golgi complex, endosome, and plasma membrane. Related genes in other species link the family to peptidyl-prolyl isomerase activity (EC 5.2.1.8) and photochemical quenching.