HMA1 — Lactuca sativa

Summary

LsHMA1, encoded by the gene LSAT_V11C600326090 on chromosome 6 of garden lettuce (Lactuca sativa), is a P-type ATPase with domains including ATPase_P-typ_cyto_dom_N and HAD_sf. It is associated with multiple cation transport activities, including copper, zinc, cadmium, and calcium transmembrane transporter activity, as well as histone methylase activity. The gene is linked to detoxification of zinc, copper, and cadmium ions, copper ion homeostasis, and the photosynthetic electron transport chain. It is associated with traits such as copper sensitivity, drought tolerance, disease tolerance, plant height, flowering time, leaf senescence, root development, and stomatal opening. Localization evidence places the product at the chloroplast thylakoid membrane, vacuolar membrane, and chromatin. Studies of related genes in other species link the family to heavy metal tolerance, copper transport, and stress adaptation.