GRF3 — Lactuca sativa

Summary

LsGRF3 (GRF3) on chromosome 5 of garden lettuce encodes a growth-regulating factor (GRF) protein containing QLQ and WRC domains and is annotated as a transcription coactivator with ATP and protein binding activity. It is localized to the nucleus and is associated with responses to deep water, cold, and gibberellin, as well as cell population proliferation, cell cycle regulation, root meristem growth, seed development, and adaxial/abaxial pattern specification. The gene has been linked to numerous agronomically relevant traits including seed weight, leaf morphology and size, water use efficiency, anthocyanin content, root oxidative activity, and floral and gynoecium development. It is also connected to phosphate acquisition, resistance to Plum pox virus, drought tolerance, and stomatal development. Related genes in other species link the GRF family to organ growth, cell proliferation, leaf development, and regeneration efficiency.